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Test Code CORT2 Cortisol, Serum


Ordering Guidance


For patients taking exogenous glucocorticoids, order CORTU / Cortisol, Free, 24 Hour, Urine.

 

This test is not recommended for evaluating response to metyrapone; DOC / 11-Deoxycortisol, Serum is more reliable.

 

A low plasma cortisol level does not give conclusive indication of congenital adrenal hyperplasia. DOC; OHPG / 17-Hydroxyprogesterone, Serum; or DHEA_ / Dehydroepiandrosterone (DHEA), Serum provide a better, accurate, and specific determination of the enzyme deficiency.



Necessary Information


Include time of collection.



Specimen Required


Patient Preparation: For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.6 mL

Collection Instructions:

1. Morning (8 a.m.) and afternoon (4 p.m.) specimens are preferred.

2. Serum gel tubes should be centrifuged within 2 hours of collection.

3. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.

Additional Information: If multiple specimens are drawn, send separate order for each specimen.


Useful For

Distinguishing between primary and secondary adrenal insufficiency

Differential diagnosis of Cushing syndrome

Method Name

Electrochemiluminescent Immunoassay (ECLIA)

Reporting Name

Cortisol, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  365 days
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia OK

Reference Values

<1 month: 0.5-14 mcg/dL

1 month- <12 months: 0.7-20 mcg/dL

1 year- <12 years: 2.4-15 mcg/dL

12 years- <18 years: 3.6-17 mcg/dL

≥ 18 years:

a.m.: 4.8-20 mcg/dL

p.m.: 2.5-12 mcg/dL

Performing Laboratory

MCHS- Mankato

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82533

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CORT2 Cortisol, S 87429-7

 

Result ID Test Result Name Result LOINC Value
CORTZ Cortisol, Random, S 83088-5
CAM1 Cortisol AM, S 9813-7
CPM1 Cortisol PM, S 9812-9

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 3 days